Is using progesterone cream dangerous?

Are you interested in using progesterone cream? You might have heard about possible side effects or things to avoid. In this blog, we will explore what is commonly said about it.


 

Is bio-identical progesterone cream dangerous?

Progesterone cream is often used as a natural hormone replacement therapy to treat hormonal imbalances in women. Although it is popular, there are many misconceptions and exaggerated stories about its potential side effects. We occasionally receive emails from women who are afraid to use it because they have heard it can cause cancer and other severe side effects.
It is important to understand whether these side effects are truly dangerous or simply myths. By gaining more information, you can make an informed decision about using progesterone cream for your specific needs.
In this blog, we will discuss common concerns and questions people have about progesterone cream. We will consult science and research studies.

 

What is bio-identical progesterone cream?

Bio-identical progesterone cream is a form of hormone therapy used to supplement or regulate the level of progesterone in the body. Progesterone is a naturally occurring hormone in the female body that plays a crucial role in regulating the menstrual cycle and pregnancy.

What makes this cream "bio-identical" is that the form of progesterone used has the same molecular structure as the progesterone naturally produced in the body. This contrasts with some other forms of hormone therapy that use synthetic hormones which do not exactly match the body's natural hormones. Typically, synthetic hormones are associated with (severe) side effects.

Bio-identical progesterone cream is usually applied to the skin and, in some cases, used vaginally. It is often used by women experiencing symptoms of hormonal imbalance, such as PMS and menopausal symptoms.
The use of bio-identical hormones is a topic of debate within the medical community. Some doctors and patients prefer bio-identical hormone therapy as it is considered more natural, while others point to the lack of long-term research on its effects and the importance of medical supervision when using it.

 

Does bio-identical progesterone cream work?

Numerous studies and research have been conducted to evaluate the effectiveness and safety of progesterone cream, especially in the context of hormone replacement therapy (HRT) and managing hormonal imbalances. Here are some key findings:
 

Reducing menopausal symptoms

Several studies have shown that progesterone cream can be effective in reducing menopausal symptoms such as hot flashes and night sweats. These studies have indicated that bio-identical progesterone cream can provide as much relief as synthetic hormone therapy, but with potentially fewer side effects.

 

Maintaining bone density

Research shows that when combined with estrogen in menopausal women, progesterone can help maintain bone density and reduce the risk of osteoporosis.


 

Using progesterone cream for endometriosis

Progesterone cream is sometimes used as part of the treatment for endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus. Studies have shown that it can help reduce pain and improve the quality of life for women with this condition.


 

Regulating menstruation

Progesterone cream can be used to regulate the menstrual cycle in women with irregular periods, such as those with polycystic ovary syndrome (PCOS). It can also be used to induce menstruation in cases of amenorrhea.


 

Fertility treatments with progesterone cream

In some cases, progesterone cream is prescribed as part of fertility treatments, such as in vitro fertilization (IVF) and for preventing miscarriages.


 

Improved sleep

Progesterone cream is successfully used to improve sleep quality.


 

Mood improvement

Women have reported a positive impact on their mood after starting progesterone cream, making them less irritable or anxious.


 

Side effects of progesterone cream

Skin irritation

Occasionally, skin irritation at the application site is reported as a side effect. This can lead to redness, itching, burning, or rash. It may help to vary the application site and ensure the skin is clean and dry before applying the cream.

 

Changes in menstruation

Progesterone can affect menstruation. Some women report light spotting or changes in their menstrual cycle. This is usually temporary. When I started using it in my early 50s, I hadn't menstruated for a year. The first two months, I had a very heavy period, but after that, it stopped completely, and I no longer had any complaints.

 

Fatigue and drowsiness

Some people experience fatigue, drowsiness, or a feeling of lethargy as a side effect. My advice is to apply it only in the evening.

 

Mood changes

Although progesterone is often associated with a calming effect, some women experience mood swings, irritability, or depression. This is usually short-lived and disappears once hormones are balanced.

 

Nausea or vomiting

In rare cases, nausea and vomiting can occur as side effects of progesterone cream. I have never encountered this in my clients.

 

Breast tenderness

Progesterone can increase breast sensitivity in some women. This usually subsides after a few months. For me, it remains to some extent, but not in a bothersome way.

 

Headaches

Headaches are occasionally reported as a side effect of progesterone cream. These typically resolve once hormonal balance is achieved. For me, headaches indicate that I have not applied the cream for too long, so it's quite the opposite.

 

Weight changes

Some people experience weight changes, such as weight gain or loss, due to using progesterone cream. Weight loss is often one of the reasons women start using it. Increased fluid retention can sometimes occur, but this usually amounts to about half a kilogram. If you measure your body fat percentage, you will see that you are losing fat. For me, the fluid mostly goes to my breasts, making them firmer.
It is important to note that not everyone will experience side effects, and if they do, they are usually mild and temporary.

 

Understanding the proper use and dosage of progesterone cream

The proper use and dosage of progesterone cream should be tailored individually, according to the insights of Dr. John R. Lee, a known advocate of natural hormone replacement therapy. Dr. Lee emphasized that progesterone cream is generally considered safer than synthetic hormone therapy. Here are his guidelines for using progesterone cream:

Individual dosing: The dosage should be adjusted based on the patient's hormonal needs, ranging from 20 mg to 40 mg per day, and can be modified based on hormone level tests.
Application method: Progesterone cream is usually applied topically to the skin, often on areas such as the inner elbows or knees, but it can also be used vaginally.
Timing: Initially, it is recommended to apply the cream twice a day because the half-life can drop too much otherwise. Once balanced, you can switch to once daily.
Duration: Progesterone cream is often used continuously to maintain hormonal balance. The duration of treatment varies based on individual needs. I sometimes take a break, but I find it better to maintain a structured routine.
Side effects

Be aware of possible side effects, but understand that bio-identical progesterone cream is generally considered safer than synthetic hormone therapy. Side effects can occur if used excessively for a prolonged period. Initially, symptoms may worsen as your hormones are not yet balanced. Do not panic; this will pass. If you have concerns, email me.
Dr. John R. Lee emphasized that side effects are generally mild and rare.

 

Misconceptions about progesterone cream

Progesterone cream is the same as synthetic progestins: Progesterone cream contains bio-identical progesterone with the same molecular structure as the naturally occurring hormone, unlike synthetic progestins which have different structures and may cause other side effects.
Progesterone cream is only useful for menopausal women: Progesterone cream can be used for various medical purposes, including regulating the menstrual cycle, treating endometriosis, promoting fertility, and reducing symptoms in women of all ages.
Progesterone cream is risky and causes severe side effects: Bio-identical progesterone cream is generally considered safer than synthetic hormone therapy. Severe side effects are rare and usually result from incorrect use or dosage.
All progesterone creams are the same: Not all progesterone creams are equal. They can have different concentrations and formulations. It's important to choose a high-quality product. I do not recommend other brands because I am not familiar with their quality.
Progesterone cream is always effective in treating hormonal problems: The effectiveness can vary depending on individual needs and the underlying medical condition. It is not always the right choice for every situation.

Weighing the risks and benefits of progesterone cream, like any medical treatment, is crucial for making informed decisions about its use.